Related Experiment Video
Updated: May 14, 2026
06:11
Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection
Published on: May 17, 2024
Sleep-disordered breathing and daytime napping are associated with maternal hyperglycemia
Bilgay Izci Balserak1, Nicholas Jackson, Sarah A Ratcliffe
1Centre for Sleep and Circadian Neurobiology, University of Pennsylvania School of Medicine, 3624 Market Street, Suite 205, Philadelphia, PA 19104, USA. Bilgay.Izci-Balserak@uphs.upenn.edu
Sleep & Breathing = Schlaf & Atmung
|January 29, 2013
Summary
Sleep-disordered breathing symptoms and daytime napping are linked to hyperglycemia in pregnant women. Sleep duration itself was not associated with increased glucose challenge test levels, suggesting further research into gestational diabetes risk factors.
Area of Science:
- Obstetrics and Gynecology
- Sleep Medicine
- Metabolic Health
Background:
- Sleep disturbances during pregnancy can negatively impact glucose metabolism.
- Gestational diabetes mellitus (GDM) is a significant concern, and identifying early risk factors is crucial.
Purpose of the Study:
- To investigate the association between sleep-disordered breathing (SDB) symptoms, sleep duration, and nap duration with 1-hour glucose challenge test (GCT) levels in pregnant women.
- To control for known risk factors for gestational diabetes in the analysis.
Main Methods:
- A case-control study involving 104 pregnant women.
- Participants underwent polysomnography, a GCT, and completed sleep quality and apnea prediction questionnaires.
- Bivariate and multivariable logistic regression analyses were used to assess outcomes.
Main Results:
- Habitual snoring was significantly more prevalent in women with hyperglycemia (GCT ≥ 135) compared to those with normoglycemia (p < 0.001).
- SDB symptoms (OR 3.37; p = 0.005) and nap duration (OR 1.64; p = 0.05) remained associated with hyperglycemia after adjusting for confounders.
- The apnea-hypopnea index in the first trimester was not significantly associated with hyperglycemia (OR 1.03; p = 0.77).
Conclusions:
- Symptoms of sleep-disordered breathing and longer nap durations are associated with maternal hyperglycemia during pregnancy.
- Overall sleep duration did not show a significant association with hyperglycemia.
- Further research is warranted to determine if SDB symptoms or daytime napping increase the risk for developing gestational diabetes.
Related Concept Videos
01:20Pathophysiology of Diabetes
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
01:26Hypoglycemia
Hypoglycemia is a blood glucose level below 70 mg/dL. It commonly occurs in individuals using insulin or insulin-secreting drugs, but may also arise in non-diabetic conditions. People with type 1 diabetes are at the highest risk because they depend on exogenous insulin. People with type 2 diabetes are also at risk, especially when treated with insulin or medications such as sulfonylureas, which increase insulin release regardless of blood glucose levels. It develops when insulin levels exceed...
01:22Diabetes Mellitus: Type 2 and Gestational
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
01:29Hyperglycemia
Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
01:26Diabetes Mellitus: Introduction
Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and long-term...
01:19Type I Diabetes III: Clinical Manifestations
Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...