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Related Experiment Video

Updated: May 14, 2026

Culturing and Manipulation of O9-1 Neural Crest Cells

Culturing and Manipulation of O9-1 Neural Crest Cells

Published on: October 9, 2018

The Hippo size control pathway--ever expanding.

Jane I Lin¹, Carole L C Poon, Kieran F Harvey

¹Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, Victoria 3002, Australia.

Science Signaling

|January 29, 2013

Summary

This summary is machine-generated.

The Hippo pathway, crucial for organ size and cancer, is regulated by Yes-associated protein (YAP). PTPN14 (Pez) antagonizes YAP, while protease-activated receptors activate it, revealing new regulatory mechanisms.

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Area of Science:

Cell Biology
Molecular Biology
Cancer Research

Background:

The Hippo pathway is a critical regulator of organ size and tumorigenesis.
The oncoprotein Yes-associated protein (YAP) is a key component of the Hippo pathway, and its regulation is increasingly complex.
Understanding YAP regulation is vital for comprehending both normal physiology and disease states.

Purpose of the Study:

To investigate the regulatory mechanisms controlling the Hippo pathway, specifically focusing on the role of YAP.
To identify novel proteins and pathways that interact with and modulate YAP activity.
To explore the functional significance of these regulatory interactions in cellular processes and disease.

Main Methods:

Utilized Drosophila models to study the in vivo function of Pez (PTPN14) as a repressor of epithelial proliferation.
Employed mammalian cell culture systems to examine the interaction between protease-activated receptors and YAP.
Investigated the role of PTPN14 (Pez) in antagonizing YAP function by promoting its cytoplasmic localization.

Main Results:

PTPN14 (Pez) was identified as an antagonist of YAP, promoting its cytoplasmic localization under conditions of high cell density.
In Drosophila, Pez was confirmed to repress epithelial proliferation in vivo.
Protease-activated receptors were found to function as activators of YAP in mammalian cells.

Conclusions:

These findings reveal intricate regulatory mechanisms governing the Hippo pathway and YAP activity.
PTPN14 (Pez) and protease-activated receptors represent newly discovered links in YAP regulation.
Further investigation of these regulatory interactions is essential for understanding their roles in physiological and pathological contexts.