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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
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Osteoporosis in men: recent progress.

Robert A Adler1

  • 1Endocrinology and Metabolism (111P), McGuire Veterans Affairs Medical Center, Virginia Commonwealth University School of Medicine, 1201 Broad Rock Boulevard, Richmond, VA 23249, USA. robert.adler@va.gov

Endocrine
|January 29, 2013
PubMed
Summary
This summary is machine-generated.

Osteoporosis in men is a growing concern, with tools like FRAX identifying many older men at high fracture risk. Treatments effective in women also show promise for men, highlighting the need for increased diagnosis and treatment.

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Area of Science:

  • Geriatric Medicine
  • Endocrinology
  • Orthopedics

Background:

  • Osteoporosis in men is an increasingly recognized clinical issue.
  • Aging male populations and increased longevity contribute to a higher prevalence of osteoporotic fractures.
  • Existing fracture risk assessment tools, such as FRAX (Fracture Risk Assessment Tool), indicate a significant portion of older men are at elevated risk.

Purpose of the Study:

  • To review current knowledge on the scope, pathophysiology, evaluation, and treatment of osteoporosis in men.
  • To highlight the evolving understanding of risk factors, including the role of sex steroids.
  • To emphasize the need for improved diagnosis and treatment of this often-neglected condition in men.

Main Methods:

  • Review of recent literature and clinical studies on male osteoporosis.
  • Analysis of data from fracture risk calculators and their application in men.
  • Examination of evidence for osteoporosis treatments in both male and female populations.

Main Results:

  • Fracture risk calculators identify a substantial number of older men at high risk.
  • The distinction between primary and secondary osteoporosis is often blurred by multiple contributing factors in men.
  • Emerging evidence suggests treatments that reduce fracture risk in women are also effective in men.

Conclusions:

  • Osteoporosis in men requires greater clinical attention due to increasing longevity and potential for fatal fractures.
  • Further research and clinical guidelines are improving the evidence base for effective treatments.
  • Increased evaluation and treatment of male osteoporosis are crucial to address this neglected health problem.