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Related Experiment Video

Updated: May 14, 2026

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

Microglia: key elements in neural development, plasticity, and pathology.

Ukpong B Eyo¹, Michael E Dailey

¹Department of Biology, University of Iowa, Iowa City, IA 52242, USA.

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on Neuroimmune Pharmacology

|January 29, 2013

Summary

This summary is machine-generated.

Microglia, the nervous system's "third element," play crucial roles in brain development, function, and disease. Advanced imaging reveals their dynamic behaviors and potential as therapeutic targets for neurological conditions.

Related Experiment Videos

Last Updated: May 14, 2026

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

Area of Science:

Neuroscience
Cell Biology

Background:

Microglia, identified by Cajal, are key components of the nervous system.
Recent advancements are clarifying microglial identity and function.

Purpose of the Study:

To review recent findings on microglial behavior and function, particularly from imaging studies.
To explore the roles of microglia in brain development, pathology, and potential therapeutic applications.

Main Methods:

In vivo imaging in adult rodent central nervous system (CNS).
Ex vivo imaging in mammalian tissue preparations.
Imaging studies in model organisms like zebrafish.

Main Results:

In vivo imaging provides new views of microglial behavior in the uninjured adult brain.
Microglia are involved in synapse remodeling, apoptosis, phagocytosis, and angiogenesis during development.
Microglia contribute to neurodevelopmental disorders, ischemic injury, and neuropathic pain.

Conclusions:

Microglia have diverse roles in neural development, behavior, and pathology.
Neuroimaging techniques are essential for understanding and targeting microglia for therapeutic intervention.