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Updated: May 14, 2026

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

Blood plasma separation in elevated dimension T-shaped microchannel.

Siddhartha Tripathi¹, Amit Prabhakar, Nishant Kumar

¹Department of Mechanical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.

Biomedical Microdevices

|January 29, 2013

Summary

This study introduces a novel microfluidic chip for efficient plasma separation using hydrodynamic techniques in millimeter-sized channels, achieving nearly 100% efficiency. The method extends the Zweifach-Fung bifurcation law to larger dimensions, simplifying device fabrication.

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Area of Science:

Biomedical Engineering
Fluid Dynamics
Microfluidics

Background:

Microfluidic chips are vital for biochemical analysis, requiring efficient plasma separation.
Existing methods use small microchannels, limiting scalability and fabrication ease.
Continuous flow separation in microfluidic devices often requires channels similar in size to blood cells.

Purpose of the Study:

To demonstrate plasma separation using hydrodynamic techniques in millimeter-sized microchannels.
To extend the applicability of the Zweifach-Fung bifurcation law to microchannels larger than suspended particle size.
To develop a simpler and highly efficient microfluidic device for blood plasma separation.

Main Methods:

Utilized hydrodynamic separation techniques in T-microchannel devices fabricated with polydimethylsiloxane (PDMS) micro-molding.
Exploited plasma skimming phenomenon based on the Zweifach-Fung bifurcation law.
Investigated the influence of feed hematocrit, main channel width, and flow rate distributions on separation efficiency.

Main Results:

Achieved a plasma separation efficiency of 99.7% at a high flow ratio.
Demonstrated the applicability of the Zweifach-Fung bifurcation law in millimeter-sized channels.
Identified key parameters influencing device efficiency and proposed novel multi-stage channel designs.

Conclusions:

The developed microfluidic device offers a highly efficient and simpler alternative for blood plasma separation.
The findings extend the understanding of hydrodynamic separation principles in microfluidics.
The technique is significant for its potential in creating easily fabricated, high-performance microfluidic systems.