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Related Concept Videos

Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate.

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Related Experiment Video

Updated: May 14, 2026

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy
12:26

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Published on: January 29, 2022

Triggering cell adhesion, migration or shape change with a dynamic surface coating.

Stijn F M van Dongen1, Paolo Maiuri, Emmanuelle Marie

  • 1École Normale Supérieure, Department of chemistry, UMR 8640 CNRS-ENS-UPMC, Paris, France. ENS@StijnvanDongen.nl

Advanced Materials (Deerfield Beach, Fla.)
|January 29, 2013
PubMed
Summary
This summary is machine-generated.

A new cell-repellent coating, azido-[polylysine-g-PEG] (APP), enables precise control over cell adhesion on surfaces. This technique allows for dynamic cell patterning and manipulation in various biological applications.

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Last Updated: May 14, 2026

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Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation

Published on: January 20, 2018

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Surface Chemistry

Background:

  • Controlling cell adhesion is crucial for tissue engineering and cell-based assays.
  • Existing methods for dynamic cell adhesion control can be complex or limited in scope.

Purpose of the Study:

  • To develop a simple and effective method for achieving spatially controlled dynamic cell adhesion.
  • To demonstrate the versatility of the developed technique in various biological applications.

Main Methods:

  • Utilized azido-[polylysine-g-PEG] (APP) as a cell-repellent coating.
  • Functionalized the APP coating with peptides to trigger cell adhesion.
  • Introduced the functional peptide via the culture medium for rapid cell adhesion induction.

Main Results:

  • Achieved rapid and triggered cell adhesion on APP-coated substrates.
  • Demonstrated successful patterned co-culturing of cells.
  • Showcased dynamic control over cell shape and tissue motility.

Conclusions:

  • APP-based substrates offer a highly accessible and powerful platform for dynamic cell adhesion control.
  • The technique facilitates diverse applications in cell biology and tissue engineering.
  • This method provides a versatile tool for creating complex cellular architectures and studying cell behavior.