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Updated: May 14, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Published on: December 4, 2016

Genetic tools to manipulate MRI contrast.

Raag D Airan¹, Nan Li, Assaf A Gilad

¹Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

NMR in Biomedicine

|January 29, 2013

Summary

Optogenetics combined with functional MRI (fMRI) allows real-time visualization of neural processes. This powerful tool investigates the cellular and molecular basis of brain activity and network changes.

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In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice

Published on: July 22, 2014

Area of Science:

Neuroscience
Molecular Biology
Medical Imaging

Background:

Early 1970s molecular biology advances spurred demand for real-time biological process visualization.
Magnetic Resonance Imaging (MRI) offered versatile contrast mechanisms suitable for dynamic biological changes.
Genetic engineering tools, including reporters, sensors, and transgenic/knockout mouse imaging, are integrated with MRI.

Purpose of the Study:

To explore the combination of optogenetics and functional MRI (fMRI) for in vivo cellular and neural process investigation.
To leverage optogenetics' ability to control genetically defined cells with light for enhanced MRI studies.
To resolve pre-synaptic versus post-synaptic neuronal activity and network plasticity.

Main Methods:

Utilizing optogenetics to manipulate cellular behavior with light in a magnetically inert manner.
Employing advanced functional MRI (fMRI) techniques to visualize real-time biological changes.
Integrating optogenetics with fMRI to probe in vivo neural processes at cellular and molecular levels.

Main Results:

Demonstrated that optogenetics and fMRI combination provides a platform to study the neuronal basis of fMRI signals in vivo.
Showcased the potential to differentiate pre-synaptic and post-synaptic neuronal activity.
Enabled the investigation of large neuronal network activity in the context of plasticity, development, learning, and pathophysiology.

Conclusions:

The synergy between optogenetics and fMRI offers unprecedented insights into neural circuit function.
This combined approach is crucial for understanding the molecular and cellular underpinnings of brain activity.
Future research can utilize this platform to explore complex neurological conditions and cognitive processes.