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Updated: May 14, 2026
09:37
Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
Published on: October 18, 2019
Alkyne metathesis on the rise.
1Max-Planck-Institut für Kohlenforschung, 45470 Mülheim/Ruhr, Germany. fuerstner@kofo.mpg.de
Angewandte Chemie (International Ed. in English)
|January 29, 2013
Summary
Alkyne metathesis, once limited in synthetic impact, is now poised for wider application. Advanced catalysts offer high activity and functional-group tolerance, enabling complex molecule synthesis.
Area of Science:
- Organic Chemistry
- Catalysis
- Synthetic Methodology
Background:
- Alkyne metathesis transformation discovery and early mechanistic validation.
- Limited synthetic utility despite available catalysts and validated mechanisms.
- Recent advancements in catalyst technology.
Purpose of the Study:
- To highlight the recent surge in alkyne metathesis applications.
- To underscore the impact of new catalyst generations on synthetic chemistry.
- To promote broader adoption of alkyne metathesis in organic synthesis.
Main Methods:
- Review of recent literature on alkyne metathesis catalysts and applications.
- Analysis of catalyst performance metrics: activity, functional-group tolerance, and reliability.
- Discussion of post-metathetic transformations and their synthetic scope.
Main Results:
- Development of highly active, functional-group-tolerant, and reliable alkyne metathesis catalysts.
- Demonstration of diverse synthetic applications enabled by these advanced catalysts.
- Facilitation of numerous post-metathetic transformations for structural diversification.
Conclusions:
- Alkyne metathesis is transitioning from limited use to broad synthetic utility.
- Modern catalysts are user-friendly (benchtop) and highly effective.
- The reaction is now accessible for widespread use in organic synthesis.
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