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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for their...
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...

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Related Experiment Video

Updated: May 14, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

The cost of implementing a nationwide program to decrease the epilepsy treatment gap in a high gap country.

Gretchen L Birbeck1, Elwyn Chomba, Edward Mbewe

  • 1Michigan State University, International Neurologic and Psychiatric Epidemiology Program, USA, Chikankata Health Services, Epilepsy Care Team, Zambia;

Neurology International
|January 29, 2013
PubMed
Summary

Implementing World Health Organization epilepsy care guidelines at the primary care level is a cost-effective strategy. This approach can significantly reduce the epilepsy treatment gap in low-income countries for under $25 per person annually.

Keywords:
Africa.costepilepsytreatment gap

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Stereo-Electro-Encephalo-Graphy (SEEG) With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note
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Stereo-Electro-Encephalo-Graphy (SEEG) With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note

Published on: June 13, 2016

Related Experiment Videos

Last Updated: May 14, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

Stereo-Electro-Encephalo-Graphy (SEEG) With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note
05:54

Stereo-Electro-Encephalo-Graphy (SEEG) With Robotic Assistance in the Presurgical Evaluation of Medical Refractory Epilepsy: A Technical Note

Published on: June 13, 2016

Area of Science:

  • Global Health
  • Neurology
  • Health Economics

Background:

  • Healthcare systems in low-income countries are ill-equipped to manage the rising burden of chronic non-communicable diseases.
  • Epilepsy is a prevalent neurological condition, yet the treatment gap exceeds 90% in many African nations due to inadequate care structures.
  • Affordable antiepileptic drugs exist, but access remains a significant challenge.

Purpose of the Study:

  • To estimate the direct costs of providing epilepsy care at the primary healthcare level, incorporating training and social marketing.
  • To develop and model a cost-effective epilepsy care delivery system utilizing primary healthcare workers.
  • To assess the economic feasibility of implementing evidence-based epilepsy care guidelines in resource-limited settings.

Main Methods:

  • Modeled epilepsy care delivery by primary healthcare workers based on WHO guidelines.
  • Estimated comprehensive direct costs, including healthcare worker retraining, social marketing, and capital expenditures.
  • Conducted sensitivity analyses to evaluate the impact of cost variations on overall care delivery expenses.

Main Results:

  • Epilepsy care, even with added costs for training and marketing, can be delivered for less than $25 per person with epilepsy annually.
  • This cost is substantially lower than drug-only costs for other common chronic conditions.
  • The proposed model demonstrates a highly cost-effective approach to epilepsy management.

Conclusions:

  • Implementing WHO epilepsy care guidelines at the primary care level is a viable and cost-effective strategy.
  • This approach offers a sustainable solution for reducing the significant epilepsy treatment gap in high-gap, low-income countries.
  • Investing in primary care-based epilepsy management can yield substantial improvements in patient outcomes and health system efficiency.