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Deficiency of a new protein associated with cardiac syndrome X; called adropin

Ahmet Celik1, Mehmet Balin, Mehmet Ali Kobat

  • 1Department of Cardiology, Elazig Education and Research Hospital, Elazig, Turkey. ahmetcelik39@hotmail.com

Cardiovascular Therapeutics
|January 30, 2013
PubMed

Insights

Lower serum adropin levels are linked to cardiac syndrome X (CSX). Adropin is identified as an independent risk factor, suggesting its potential role in CSX pathophysiology and as a diagnostic marker.

Area of Science:

  • Cardiology
  • Endocrinology
  • Biochemistry

Background:

  • Cardiac Syndrome X (CSX) pathophysiology remains unclear, though endothelial dysfunction is common.
  • Adropin is known to uniquely regulate endothelial function, making it a potential factor in CSX.

Purpose of the Study:

  • To investigate the role of adropin in patients diagnosed with Cardiac Syndrome X.
  • To assess the correlation between serum adropin levels and CSX.

Main Methods:

  • Compared serum adropin and nitrite/nitrate levels in 86 CSX patients and 86 healthy controls.
  • Utilized multiple linear regression and ROC curve analysis to determine risk factors and predictive ability.

Main Results:

  • CSX patients had significantly lower serum adropin (1.7 vs. 3.4 ng/mL) and nitrite/nitrate levels (15.9 vs. 25.4 μmol/L).
  • Adropin levels positively correlated with nitrite/nitrate levels (r=0.463).
  • Adropin, BMI, and nitrite/nitrate levels were independent risk factors for CSX; adropin showed high predictive ability (AUC=0.854, sensitivity=90.7%, specificity=70.9%).

Conclusions:

  • Lower serum adropin levels are associated with Cardiac Syndrome X.
  • Adropin is an independent risk factor for CSX, highlighting its potential clinical significance.

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