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Association between paraoxonase gene and stroke in the Han Chinese population

Guojun Zhang1, Wenjin Li, Zhiqiang Li

  • 1Laboratory Diagnosis Center, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China.

BMC Medical Genetics
|January 30, 2013
PubMed

Insights

Genetic variants in the paraoxonase (PON1) gene are linked to stroke risk. Specifically, the rs705381 polymorphism in PON1 is associated with reduced risk of total and ischemic stroke in the Han Chinese population.

Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Epidemiology

Background:

  • The paraoxonase (PON) gene family (PON1, PON2, PON3) plays a role in preventing oxidative modification of low-density lipoproteins and atherosclerosis.
  • Genetic variations in PON genes are investigated for their potential association with cerebrovascular disease risk.

Purpose of the Study:

  • To evaluate the association between genetic variants of all three PON genes and the risks of total, ischemic, and hemorrhagic stroke.
  • To investigate the role of PON gene polymorphisms in stroke occurrence within the Han Chinese population.

Main Methods:

  • A case-control study involving 1016 participants (508 controls, 498 stroke patients).
  • Genotyping of 11 single nucleotide polymorphisms (SNPs) across the PON genes.
  • Statistical analysis including a dominant model for association and a meta-analysis for specific SNPs (rs662, rs854560) in ischemic stroke.

Main Results:

  • The PON1 promoter polymorphism rs705381 (-162) showed a significant association with reduced risk of total stroke (OR=0.57) and ischemic stroke (OR=0.54) under a dominant model.
  • No significant association was found between rs705381 and hemorrhagic stroke.
  • A nominal association was observed between rs854571 (-824) and total stroke. Meta-analysis indicated a nominal association between rs662 and ischemic stroke.

Conclusions:

  • Polymorphisms in the PON1 gene may represent a risk factor for stroke.
  • The rs705381 variant in PON1 is associated with a decreased risk of ischemic stroke in the studied population.
Abstract

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