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Intracellular Staining and Flow Cytometry to Identify Lymphocyte Subsets within Murine Aorta, Kidney and Lymph Nodes in a Model of Hypertension
Published on: January 28, 2017
Association between CD8+ T-cell subsets and cardiovascular disease.
D Kolbus1, I Ljungcrantz, L Andersson
1Department of Clinical Sciences Malmö, Lund University, Sweden.
Journal of Internal Medicine
|January 30, 2013
Summary
High CD8(+) T cells are linked to increased cardiovascular events and insulin resistance. Specific CD8(+) T-cell subsets correlate with carotid stenosis severity, indicating their role in atherosclerosis.
Area of Science:
- Immunology
- Cardiovascular Medicine
- Atherosclerosis Research
Background:
- Experimental studies suggest immune system involvement in atherosclerosis.
- Clinical significance of specific immune cells in cardiovascular disease is not well understood.
Purpose of the Study:
- Investigate the association between CD8(+) T cells and carotid disease.
- Examine the link between CD8(+) T cells and cardiovascular disease events.
Main Methods:
- Analyzed 700 subjects from the Malmö Diet and Cancer Study.
- Used flow cytometry to assess CD8(+) T-cell populations in stored peripheral blood mononuclear cells.
- Assessed carotid intima-media thickness, stenosis via ultrasonography, and monitored clinical events.
Main Results:
- Higher CD8(+) T-cell fractions correlated with decreased cytokine release, insulin resistance, and increased coronary events.
- Significant associations found between CD8(+) CD25(+) T cells and carotid stenosis degree.
- CD8(+) CD56(-) IFN-γ(+) T-cell fraction linked to carotid stenosis, even after risk factor adjustment.
Conclusions:
- Provides prospective clinical evidence for CD8(+) T cells in cardiovascular disease.
- Suggests distinct CD8(+) T-cell subsets possess varying pathological roles in atherosclerosis.
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