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Myasthenia Gravis ll: Pathophysiology

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The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...

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Related Experiment Video

Updated: May 14, 2026

Isolation and Culture of Individual Myofibers and their Satellite Cells from Adult Skeletal Muscle

Isolation and Culture of Individual Myofibers and their Satellite Cells from Adult Skeletal Muscle

Published on: March 22, 2013

Myospherulosis.

Veit Phillip¹, Karen Becker, Monther Bajbouj

¹II. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Str. 22, 81675 München, Germany. phillip@lrz.tum.de

Annals of Diagnostic Pathology

|January 30, 2013

Summary

This summary is machine-generated.

Myospherulosis, a rare tumor involving lipids and red blood cells, can affect any body part but often appears in the paranasal sinus. Surgical excision typically cures this benign condition.

Keywords:

Erythrocytes Lipids Spherulocystic disease Spherulocytosis

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Published on: July 1, 2020

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Last Updated: May 14, 2026

Isolation and Culture of Individual Myofibers and their Satellite Cells from Adult Skeletal Muscle

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Published on: March 22, 2013

Single Myofiber Isolation and Culture from a Murine Model of Emery-Dreifuss Muscular Dystrophy in Early Post-Natal Development

Single Myofiber Isolation and Culture from a Murine Model of Emery-Dreifuss Muscular Dystrophy in Early Post-Natal Development

Published on: July 1, 2020

Area of Science:

Pathology
Oncology
Dermatology

Background:

Myospherulosis is a rare tumor resulting from the interaction of extravasated erythrocytes and lipids.
It was first described in 1969, with 181 cases reported across 59 articles.
While it can occur anywhere, the paranasal sinus and subcutaneous tissue are the most common sites.

Purpose of the Study:

To systematically review the literature on myospherulosis.
To discuss its clinical presentation, diagnosis, and treatment.

Main Methods:

Systematic literature review of 59 articles.
Analysis of 181 patient cases.

Main Results:

Myospherulosis affects all ages and body parts, predominantly the paranasal sinus and subcutaneous tissue.
Exogenous lipids from postoperative packing are a common cause, but spontaneous cases exist.
Histology confirms diagnosis, though radiographic imaging can suggest it. Differential diagnoses include fungal/algal infections and misinterpretation as carcinomas.

Conclusions:

Myospherulosis is a benign condition with symptoms related to its space-occupying nature.
Surgical excision is curative.
Understanding its presentation, diagnosis, and treatment is crucial for patient management.