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Updated: May 14, 2026

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction
06:57

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

Published on: January 31, 2019

Coronary artery disease and ventricular tachyarrhythmia: pathophysiology and treatment

Theofilos M Kolettis1

  • 1Department of Cardiology, University of Ioannina, Greece. thkolet@cc.uoi.gr

Current Opinion in Pharmacology
|January 30, 2013
PubMed

Insights

Ventricular tachyarrhythmias, a common issue in coronary artery disease, are complex. This review covers their causes, treatments, and the effectiveness of implantable cardioverter-defibrillators (ICDs).

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Research

Background:

  • Ventricular tachyarrhythmias frequently complicate coronary artery disease.
  • Ischemia and genetic factors contribute to arrhythmias during acute myocardial infarction (MI), but mechanisms remain unclear.
  • Primary percutaneous coronary interventions (PCIs) reduce arrhythmia incidence post-MI.

Purpose of the Study:

  • To review current understanding of ventricular tachyarrhythmia pathophysiology.
  • To explore treatment strategies across different clinical stages of coronary artery disease.
  • To discuss the efficacy and limitations of current therapeutic approaches.

Main Methods:

  • Literature review of pathophysiology and treatment of ventricular tachyarrhythmias.
  • Analysis of prehospital, acute, and chronic phases of myocardial infarction.
  • Evaluation of interventions including PCIs, antiarrhythmic drugs, and implantable cardioverter-defibrillators (ICDs).

Main Results:

  • Antiarrhythmic drugs have limited value in the chronic phase.
  • Implantable cardioverter-defibrillators (ICDs) are effective for terminating arrhythmias.
  • Risk stratification for ICD candidates requires improvement.

Conclusions:

  • Understanding ventricular tachyarrhythmia mechanisms in acute MI is crucial.
  • Further research into reperfusion injury treatments is needed.
  • Improved risk stratification is essential for optimizing ICD therapy in coronary artery disease patients.

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