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Updated: May 14, 2026
06:47
Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
Published on: January 28, 2021
Lipoprotein apheresis--more than just cholesterol reduction?
Claas L Neumann1, Egbert G Schulz, Gerit C Hagenah
1Nephrologisches Zentrum Göttingen GbR, An der Lutter 24, D-37075 Goettingen, Germany.
Atherosclerosis. Supplements
|January 30, 2013
Summary
Lipoprotein apheresis effectively lowers LDL cholesterol and impacts vascular inflammation, rheology, and gene expression. This safe extracorporeal treatment also reduces oxidative stress, benefiting atherosclerosis progression.
Area of Science:
- Cardiovascular Medicine
- Lipidology
- Biotechnology
Background:
- Severe hyperlipoproteinemia requires effective lipid-lowering treatments.
- Lipoprotein apheresis is an established extracorporeal therapy for severe hyperlipoproteinemia.
- Beyond LDL reduction, apheresis may influence other atherogenic factors.
Purpose of the Study:
- To review the multifaceted effects of lipoprotein apheresis.
- To examine apheresis' impact on vascular inflammation, rheology, and gene expression.
- To assess apheresis' influence on oxidative stress and atherosclerosis progression.
Main Methods:
- Literature review of studies on lipoprotein apheresis.
- Analysis of apheresis effects on plasma and blood cell oxidative stress.
- Evaluation of apheresis' impact on atherogenic factors.
Main Results:
- Lipoprotein apheresis reduces LDL cholesterol and alters lipoprotein metabolism.
- Apheresis demonstrates beneficial effects on vascular inflammation, rheology, and gene expression.
- The treatment mitigates oxidative stress in plasma and blood cells, impacting atherosclerosis.
Conclusions:
- Lipoprotein apheresis offers benefits beyond lipid reduction.
- The therapy positively influences key factors in atherosclerosis development.
- Lipoprotein apheresis is a safe and effective biocompatible treatment modality.
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