Related Experiment Video
Updated: May 14, 2026

Predicting Catalyst Extrudate Breakage Based on the Modulus of Rupture
Published on: May 13, 2018
Modelling of the break force of tablets under diametrical compression
1Department of Engineering, University of Leicester, University Road, Leicester LE1 7RH, UK.
Abstract:
A numerical method to predict the break force of curved faced tablets is proposed. The constitutive model and the failure criteria necessary to obtain predictions consistent with experimental data are identified. A modified Drucker-Prager cap model together with a maximum principal stress based failure criteria was found sufficient to predict the break force of tablets under diametrical compression loading. The conditions for the validity of the method were identified with reference to practical tablet shapes and failure patterns. Under these conditions the numerical procedures can be used as a practical tool to predict tablet breakage as an alternative to the empirical methods currently used in pharmaceutical product design and process development.
Related Concept Videos
Behavior of Concrete Under Compressive Load
As the concrete specimen fractures under...
In Vitro Drug Dissolution: Compendial Testing Models I
In Vitro Drug Dissolution: Compendial Testing Models II
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Stress-Strain Diagram - Brittle Materials
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
