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Related Concept Videos

G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
G-protein Coupled Receptors01:21

G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical, 7TM, or...
GPCR Desensitization01:12

GPCR Desensitization

G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...

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Related Experiment Video

Updated: May 14, 2026

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors
16:16

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors

Published on: September 13, 2013

[Research progress in G protein-coupled receptor 40].

Shen Wu1, Tao-Feng Lu, Shuang Wu

  • 1Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China. kiddshenx@126.com

Yi Chuan = Hereditas
|January 30, 2013
PubMed
Summary

G protein-coupled receptor 40 (GPR40) regulates insulin release in the pancreas and neurogenesis in the brain. Research on GPR40 agonists shows potential for diabetes treatment, though its nervous system mechanisms require further study.

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Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors (GPCRs)
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Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors
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Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors

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BRET-based G Protein Biosensors for Measuring G Protein-Coupled Receptor Activity in Live Cells
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Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors (GPCRs)
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Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors (GPCRs)

Published on: February 5, 2022

Area of Science:

  • Molecular Biology
  • Neuroscience
  • Endocrinology

Context:

  • G protein-coupled receptor 40 (GPR40) is a cell surface receptor found in the pancreas and central nervous system.
  • GPR40 binds medium and long-chain fatty acids, activating intracellular signaling pathways.
  • Its role in insulin secretion from pancreatic beta-cells is established, with implications for diabetes treatment.

Purpose:

  • To review the current research progress on GPR40, focusing on its gene structure, ligands, and functions.
  • To highlight existing challenges and future research directions for GPR40.
  • To explore the potential of GPR40 agonists in managing diabetes and understanding neurogenesis.

Summary:

  • GPR40 activation by fatty acids in pancreatic beta-cells increases intracellular calcium, promoting insulin release, making it a target for diabetes therapies.
  • While GPR40's involvement in neurogenesis is recognized, the underlying mechanisms remain largely unelucidated.
  • This review synthesizes information on GPR40's characteristics, ligands, and functions, addressing current research gaps.

Impact:

  • Provides a comprehensive overview of GPR40, aiding researchers in understanding its multifaceted roles.
  • Identifies key areas for future investigation, potentially accelerating the development of novel therapeutics.
  • Contributes to the broader understanding of metabolic and neurological processes regulated by GPR40.