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Testing of Perilla frutescens extract and Vicenin 2 for their antispasmodic effect
Eugen J Verspohl1, Hajime Fujii, Kohei Homma
1Department of Pharmacology, Institute of Medicinal Chemistry, University of Münster, Münster, Germany. verspoh@uni-muenster.de
Abstract:
Gastrointestinal discomfort is frequently observed. The effects of Perilla frutescens extract and Vicenin 2 (a compound in this extract) were assayed in rat ileum with or without stimulation with acetylcholine or Ba(2+). Both had no direct spasmolytic effect, but both decreased acetylcholine- or Ba(2+)-induced contraction of rat ileum indicating an antispasmodic effect. This is valuable because effects were only observed when spasms were induced and may disturb the patient. The extract and the compound may be used to maintain and improve gut health.
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