Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Glial Cells01:04

Glial Cells

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Fluoxetine on Cognitive Functioning in Children with Down Syndrome: A Prospective Open-Label Exploratory Study of Safety and Efficacy.

Journal of child and adolescent psychopharmacology·2026
Same author

Investigating the role of neuroglobin in cholesterol metabolism: a spotlight on brain-derived cells.

Lipids in health and disease·2026
Same author

Case Report: Integration between eye movement desensitization and reprocessing and cognitive therapy for autism spectrum disorder. Novel intervention protocol based on case formulation and brief review of literature.

Frontiers in psychology·2026
Same author

Exploring novel biomarkers for endocrine disruptor exposure: insights into extra-nuclear signaling pathways of estrogen and androgen receptors.

Environmental toxicology and pharmacology·2026
Same author

Daily intranasal resveratrol-conjugated gold nanoparticles administration promotes neuroprotection and improves neurological outcome in the R6/2 mouse model of Huntington's disease.

Experimental neurology·2026
Same author

The natural L370F ERα variant confers endocrine resistance and sensitivity to ATRA in metastatic breast cancer cells.

Cell communication and signaling : CCS·2026

Related Experiment Video

Updated: May 14, 2026

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons
13:46

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons

Published on: July 11, 2020

Neuroglobin and neuronal cell survival.

Marco Fiocchetti1, Elisabetta De Marinis, Paolo Ascenzi

  • 1Department of Science, University Roma Tre, Roma, Italy.

Biochimica Et Biophysica Acta
|January 30, 2013
PubMed
Summary

Neuroglobin (NGB) protects neurons by interacting with cytochrome c in mitochondria, a process enhanced by 17β-estradiol (E2). This mechanism offers potential therapeutic strategies for neurodegenerative diseases.

Keywords:
17β-estradiolAPAF-1ApoptosisAβE2EREREERβHIF-1NGBNGB-Tg miceNGB-over-expressing transgenic miceNeuroglobinNeuroprotectionSignal transduction pathwaysTAT proteinTAT-NGBVDACVEGFamyloid-β peptidesapoptotic protease-activating factor-1estrogen receptorestrogen receptor βestrogen responsive elementshypoxia-inducible factor-1mPTPmitochondria permeability transition poreneuroglobintrans-activator of the transcription and NGBtrans-activator of the transcription proteinvascular endothelial growth factorvoltage-dependent anion channel

More Related Videos

Monitoring Neuronal Survival via Longitudinal Fluorescence Microscopy
07:02

Monitoring Neuronal Survival via Longitudinal Fluorescence Microscopy

Published on: January 19, 2019

Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons
10:53

Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons

Published on: September 15, 2014

Related Experiment Videos

Last Updated: May 14, 2026

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons
13:46

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons

Published on: July 11, 2020

Monitoring Neuronal Survival via Longitudinal Fluorescence Microscopy
07:02

Monitoring Neuronal Survival via Longitudinal Fluorescence Microscopy

Published on: January 19, 2019

Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons
10:53

Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons

Published on: September 15, 2014

Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Neuronal apoptosis and survival are critical in brain development and neurodegenerative diseases.
  • Neuroglobin (NGB), a nerve globin, may offer neuroprotection upon upregulation.
  • Existing data on NGB's role in apoptosis and mitochondrial localization are incomplete.

Purpose of the Study:

  • To review the physiological role of NGB in neuronal survival.
  • To investigate the role of 17β-estradiol (E2) in modulating NGB levels and function.
  • To explore NGB-mediated therapeutic strategies for neuroprotection.

Main Methods:

  • Review of in vitro studies on cytosolic NGB and apoptosis.
  • Identification of E2 as an endogenous modulator of NGB in neuroblastoma cells.
  • Analysis of NGB reallocation into mitochondria and its association with cytochrome c upon E2 stimulation.

Main Results:

  • E2 stimulation causes NGB to relocate to mitochondria, enhancing its association with cytochrome c.
  • E2 treatment before apoptotic stimuli reduces cytochrome c release and caspase-3 activation.
  • This suggests E2-induced NGB upregulation protects against apoptosis.

Conclusions:

  • NGB plays a crucial role in modulating neuronal survival, particularly within mitochondria.
  • 17β-estradiol enhances NGB's protective effects by promoting its mitochondrial localization and interaction with cytochrome c.
  • Targeting NGB expression or function presents a promising therapeutic avenue for neurodegenerative diseases and stroke damage.