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Related Concept Videos

Harmonic Mean01:09

Harmonic Mean

The arithmetic mean is usually skewed towards the larger values in the data set. Therefore, to avoid this inherent bias towards smaller values, the harmonic mean is used.
Take the example of the speed of a car, which is the measure of the rate of distance traveled. If the vehicle traverses the same distance back-and-forth, its average speed equals the total distance traveled divided by the total time taken. However, if the car moves with varying speeds, then the arithmetic mean is more skewed...
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Assessment of radial pulse

Assessment of Radial Pulse
The radial pulse, located at the wrist, is often the preferred site for assessing peripheral pulse because of its accessibility and dependability. The process of determining the radial pulse involves several steps:
Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...
Cerebral Hemispheres01:05

Cerebral Hemispheres

The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
Heart Sounds01:15

Heart Sounds

Heart sounds are generated by the turbulence in blood flow due to the closing of heart valves. These sounds are best perceived slightly away from the valves, where the blood flow disseminates the sound.
Auscultation is the process of listening to these internal body sounds using a stethoscope. The heart produces four types of sounds, but only two—S1 and S2—can usually be heard with a stethoscope.
S1, also known as the "lub" sound, is caused by the closure of atrioventricular (A-V) valves at the...
Diencephalon: Anatomical Regions01:30

Diencephalon: Anatomical Regions

The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the subthalamic...

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Related Experiment Video

Updated: May 14, 2026

Design, Fabrication, and Administration of the Hand Active Sensation Test (HASTe)
07:54

Design, Fabrication, and Administration of the Hand Active Sensation Test (HASTe)

Published on: September 8, 2015

What does the HAMD mean?

Stefan Leucht1, Hein Fennema, Rolf Engel

  • 1Klinik für Psychiatrie und Psychotherapie der TU-München Klinikum rechts der Isar Ismaningerstr. 22, 81675 München, Germany. Stefan.Leucht@lrz.tum.de

Journal of Affective Disorders
|January 30, 2013
PubMed
Summary
This summary is machine-generated.

The Hamilton Rating Scale for Depression (HAMD-17) scores are clinically relevant for measuring Major Depressive Disorder (MDD) severity and treatment outcomes. Established response and remission criteria align with clinical global impressions.

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Published on: September 12, 2017

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Psychopharmacology

Background:

  • The clinical interpretation of Hamilton Rating Scale for Depression (HAMD-17) total scores, including response and remission thresholds, lacks clear definition.
  • Understanding the clinical significance of HAMD-17 scores is crucial for evaluating treatment efficacy in Major Depressive Disorder (MDD).

Purpose of the Study:

  • To establish the clinical relevance of HAMD-17 total scores by linking them to Clinical Global Impression (CGI) ratings.
  • To validate commonly used HAMD-17 criteria for treatment response and remission against CGI measures.
  • To investigate the influence of baseline illness severity on the relationship between HAMD-17 and CGI scores.

Main Methods:

  • Equipercentile linking of HAMD-17 and CGI-I (Improvement) and CGI-S (Severity) ratings.
  • Analysis of data from 43 Major Depressive Disorder (MDD) drug trials, including 7131 patients.
  • Comparison of HAMD-17 score changes with CGI ratings across different baseline severity subgroups.

Main Results:

  • A CGI-I score of 2 ('much improved') correlated with a 50-60% reduction in HAMD-17 scores.
  • A CGI-I score of 1 ('very much improved') correlated with a 75-85% reduction in HAMD-17 scores.
  • HAMD-17 scores <5 aligned with CGI-S 1 ('normal'), and scores 6-8 aligned with CGI-S 2 ('borderline mentally ill').
  • Baseline illness severity impacted the observed relationships.

Conclusions:

  • The study validates the clinical utility of standard HAMD-17 response (≥50% reduction) and remission (≤7) criteria in MDD.
  • HAMD-17 scores provide a clinically meaningful measure of depression severity and treatment outcome when interpreted alongside CGI.
  • Baseline severity influences the interpretation of HAMD-17 scores, necessitating consideration in clinical practice.