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Updated: May 14, 2026
06:39
Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
Published on: August 19, 2020
[Myeloproliferative neoplasms related glomerulopathy]
R Paule1, M Ponsoye, V Gueutin
1Service de néphrologie, hôpital de Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75013 Paris, France.
La Revue De Medecine Interne
|January 30, 2013
Summary
Myeloproliferative neoplasms (MPNs) can cause a rare kidney complication called MPN-related glomerulopathy. This under-recognized condition presents with proteinuria and renal insufficiency, often with a poor prognosis.
Area of Science:
- Hematology
- Nephrology
- Oncology
Context:
- Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders.
- MPNs are characterized by myeloid lineage expansion.
- Major complications include transformation to acute myeloid leukemia and thrombotic/hemorrhagic events.
Purpose:
- To describe MPN-related glomerulopathy, an under-recognized renal complication.
- To highlight its clinical and histologic features.
- To suggest potential pathogenetic mechanisms and the need for greater awareness.
Summary:
- MPN-related glomerulopathy is a late renal complication of MPNs, infrequently observed.
- Clinically, it presents with heavy proteinuria and renal insufficiency.
- Histologically, it shows mesangial sclerosis, thrombotic microangiopathy features, and intracapillary hematopoietic cell infiltration.
Impact:
- Increases the spectrum of glomerular diseases linked to hematological neoplasms.
- Recognizing MPN-related glomerulopathy is crucial for diagnosis and developing therapies.
- Poor prognosis underscores the need for further research and clinical attention.
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