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Related Concept Videos

Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Updated: May 14, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Published on: June 16, 2020

[Schnitzler's syndrome].

B Henry1, A Néel, S Barbarot

  • 1Service de médecine interne, Hôtel-Dieu, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes, France.

La Revue De Medecine Interne
|January 30, 2013
PubMed
Summary
This summary is machine-generated.

Schnitzler syndrome (SS) is a rare autoinflammatory disorder characterized by fever, rash, and bone pain, associated with monoclonal gammopathy. Anakinra shows promise in managing severe SS cases, offering new hope for patients.

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Area of Science:

  • Rheumatology
  • Hematology
  • Immunology

Context:

  • Schnitzler syndrome (SS) is a rare autoinflammatory disorder.
  • It is associated with monoclonal gammopathy, predominantly IgM kappa.
  • Pathophysiology remains largely unknown.

Purpose:

  • To summarize the key features of Schnitzler syndrome.
  • To discuss current and emerging treatment options.
  • To highlight the long-term risks and research needs.

Summary:

  • SS presents in middle-aged adults with recurrent fever, urticarial rash, bone/joint pain, and elevated inflammatory markers.
  • Monoclonal gammopathy, typically IgM kappa, is a constant feature.
  • Anakinra has demonstrated significant efficacy in managing severe SS, revolutionizing treatment.

Impact:

  • Anakinra offers a targeted therapy for severe Schnitzler syndrome, improving patient quality of life.
  • Understanding SS pathophysiology is crucial for developing more effective treatments.
  • Long-term monitoring for lymphoproliferative disorders, such as Waldenström's macroglobulinemia, is essential.