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Published on: May 2, 2025
Application of poly-L-lactic acid nanosheet as a material for wound dressing
Shimpo Aoki1, Manabu Kinoshita, Hiromi Miyazaki
1Tokyo and Tokorozawa, Japan From the Clinic of Ichigaya, Ministry of Defense; the Departments of Immunology and Microbiology and Basic Pathology, and the Division of Traumatology, Research Institute, National Defense Medical College; and the Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University.
Abstract:
The authors evaluated the efficacy of an ultrathin nanosheet consisting of poly-L-lactic acid (75 nm thick) as a wound dressing material. A full-thickness skin defect was made on the backs of mice and overlapped with or without the poly-L-lactic acid nanosheet. Wound healing was more rapidly improved by overlapping with the nanosheet, especially in the early healing period (at 4 to 6 days). The remaining wound area in the treatment group was significantly smaller at 4 days than in the control group. Histologically, a clear layer was observed over the granulation layer by the nanosheet therapy at 4 days. Thus, overlapping therapy with the poly-L-lactic acid nanosheet accelerated wound healing and formed a clear layer just above the granulation tissue. The poly-L-lactic acid nanosheet may have potential as a novel wound dressing to promote wound healing.
