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Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
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Safety and feasibility of targeted agent combinations in solid tumours

Sook Ryun Park1, Myrtle Davis, James H Doroshow

  • 1Division of Cancer Treatment and Diagnosis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 31, Room 3A44, 31 Center Drive, Bethesda, MD 20892, USA.

Nature Reviews. Clinical Oncology
|January 30, 2013
PubMed
Summary

Combining molecular-targeted agents (MTAs) can improve cancer treatment but may cause unexpected toxicities in normal cells. New preclinical testing is needed to assess these combination toxicities.

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