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Updated: May 14, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
Regulatory T-cells in chronic lymphocytic leukemia: actor or innocent bystander?
Giovanni D'Arena1, Vittorio Simeon, Fiorella D'Auria
1Onco-Hematology Department, IRCCS Centro di Riferimento Oncologico della Basilicata Rionero in Vulture, Italy.
Abstract:
Regulatory T (Treg) cells are now under extensive investigation in chronic lymphocytic leukemia (CLL). This small subset of T-cells has been, in fact, considered to be involved in the pathogenesis and progression of CLL. However, whether Treg dysregulation in CLL plays a key role or it rather represents a simple epiphenomenon is still matter of debate. In the former case, Treg cells could be appealing for targeting therapies. Finally, Treg cells have also been proposed as a prognostic indicator of the disease clinical course.
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