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[Changes in the levels of erythrocyte membrane proteins in hypertension]
The distribution of specific proteins in erythrocyte membranes was studied in patients with essential hypertension (EH) (n = 44), secondary hypertension of renal genesis (n = 42), and healthy persons (n = 44). Densitograms of gel analyzed after electrophoresis of erythrocyte ghosts showed a twofold increase in polypeptide levels in EH patients as compared to those in health persons: the band being 4.5 (Mw = 52-59 kD) and 6 (Mw = 35 kD), respectively. Radioimmunoassay has demonstrated that the amount of monoclonal antibodies bound to fragmented erythrocyte membranes from EH patients is greater by at least 28% than that in healthy persons. Patients with secondary arterial hypertension of renal genesis showed no significant difference in monoclonal antibody binding as compared to the controls.
The distribution of specific proteins in erythrocyte membranes was studied in patients with essential hypertension (EH) (n = 44), secondary hypertension of renal genesis (n = 42), and healthy persons (n = 44). Densitograms of gel analyzed after electrophoresis of erythrocyte ghosts showed a twofold increase in polypeptide levels in EH patients as compared to those in health persons: the band being 4.5 (Mw = 52-59 kD) and 6 (Mw = 35 kD), respectively. Radioimmunoassay has demonstrated that the amount of monoclonal antibodies bound to fragmented erythrocyte membranes from EH patients is greater by at least 28% than that in healthy persons. Patients with secondary arterial hypertension of renal genesis showed no significant difference in monoclonal antibody binding as compared to the controls.