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Trabecular meshwork depigmentation in Vogt-Koyanagi-Harada disease
Kazuomi Mizuuchi1, Nobuyoshi Kitaichi, Kenichi Namba
1Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan.
Japanese Journal of Ophthalmology
|January 30, 2013
Summary
Trabecular meshwork depigmentation occurs in Vogt-Koyanagi-Harada (VKH) disease. This finding is linked to sunset glow fundus but not skin lesions.
Area of Science:
- Ophthalmology
- Immunology
Background:
- Vogt-Koyanagi-Harada (VKH) disease can cause depigmentation of ocular structures.
- The trabecular meshwork's pigmentation status in VKH disease requires further investigation.
Observation:
- This study retrospectively analyzed 53 Japanese patients with VKH disease.
- Trabecular and limbal pigmentation scores were assessed and correlated with clinical findings.
Findings:
- Significantly reduced trabecular pigmentation was observed in patients with sunset glow fundus.
- No significant correlation was found between trabecular pigmentation and skin lesions.
- No correlation was found between trabecular and limbal pigmentation.
Implications:
- Trabecular meshwork depigmentation is a feature in some VKH disease patients.
- Sunset glow fundus is a significant correlate of trabecular depigmentation in VKH.
- These findings may aid in understanding VKH disease pathogenesis and progression.
