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Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation
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Lung morphometry using hyperpolarized (129) Xe apparent diffusion coefficient anisotropy in chronic obstructive

Alexei Ouriadov1, Adam Farag, Miranda Kirby

  • 1Ph.D., Imaging Research Laboratories, Robarts Research Institute, Western University, London, Ontario, Canada.

Magnetic Resonance in Medicine
|January 30, 2013
PubMed
Summary
This summary is machine-generated.

Hyperpolarized (129) Xe MRI reveals lung morphological changes in chronic obstructive pulmonary disease (COPD). This advanced imaging technique shows promise for early emphysema detection in patients with COPD.

Keywords:
ADCanisotropyhyperpolarizedlungmorphometryxenon-129

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Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
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Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

Area of Science:

  • Pulmonary Medicine
  • Medical Imaging
  • Radiology

Background:

  • Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by airflow limitation.
  • Emphysema, a major component of COPD, involves the destruction of lung alveoli.
  • Accurate assessment of lung morphology is crucial for understanding COPD progression and developing effective treatments.

Purpose of the Study:

  • To investigate lung morphological changes in COPD using hyperpolarized (129) Xe diffusion-weighted MRI.
  • To assess the potential of this technique for early detection of emphysema.

Main Methods:

  • Hyperpolarized (129) Xe diffusion-weighted MRI was performed at three b-values (12, 20, 30 s/cm(2)) in subjects with COPD and healthy volunteers.
  • Image signal intensities were analyzed to derive anisotropic diffusion coefficients and morphological parameters (external/internal radii, mean airspace chord length, alveolar sleeve depth).

Main Results:

  • COPD subjects showed significantly increased longitudinal and transverse anisotropic diffusion coefficients compared to healthy controls.
  • Significant morphological differences included decreased alveolar sleeve depth (h) and increased mean airspace chord length (Lm) in COPD patients.
  • These findings align with previous studies using hyperpolarized (3) He MRI.

Conclusions:

  • Diffusion-weighted hyperpolarized (129) Xe MRI is a valuable tool for mapping human lung morphology.
  • This technique shows potential for the early detection of emphysema associated with COPD.
  • Further research can validate its clinical utility in COPD management.