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[Indicators of lipid peroxidation in the blood in hereditary predisposition to arteriosclerosis]

E F Davidenkova, M G Shafran, B M Veksler

    Klinicheskaia Meditsina
    |February 1, 1990
    PubMed

    Insights

    Individuals with a family history of atherosclerosis exhibit elevated lipid peroxidation products and reduced neutrophil myeloperoxidase activity. These biomarkers may indicate a subclinical predisposition to cardiovascular disease.

    Area of Science:

    • Biochemistry
    • Cardiovascular Medicine
    • Genetics

    Background:

    • Atherosclerosis is a significant cardiovascular disease with a hereditary component.
    • Understanding subclinical markers of atherosclerosis is crucial for early detection and prevention.

    Purpose of the Study:

    • To investigate the correlation between lipid peroxidation products and oxidation-antioxidation enzyme activity in individuals with a family history of atherosclerosis.
    • To identify potential biomarkers for hereditary predisposition to atherosclerotic cardiovascular disorders.

    Main Methods:

    • Serum levels of lipid peroxidation products (acylhydroperoxides, malonic dialdehyde) were measured.
    • Enzymatic activity of neutrophil myeloperoxidase, superoxide dismutase, glutathione peroxidase, and catalase in red blood cells was assessed.
    • Comparison between family members of atherosclerosis patients, clinically affected individuals, phenotypically healthy individuals, and a control group.

    Main Results:

    • Elevated plasma acylhydroperoxides and reduced neutrophil myeloperoxidase activity were observed in individuals with a hereditary predisposition to atherosclerosis.
    • Malonic dialdehyde levels were higher in the study group and those with cardiovascular disorders.
    • No significant differences in red blood cell superoxide dismutase, glutathione peroxidase, or catalase activity were found between groups.

    Conclusions:

    • Shifts in lipid peroxidation and neutrophil myeloperoxidase activity are consistent in individuals with hereditary atherosclerosis.
    • These oxidative stress markers may represent a key pathogenetic link in the development of inherited atherosclerotic cardiovascular disease.
    • Biomarker detection is feasible during the subclinical period, enabling early intervention.

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