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Published on: February 19, 2022
Gastro-intestinal stromal tumour--a case report.
S R Agashe1, P P Patil, M A Phansopkar
1Department of Pathology, Bharati Vidyapeeth University Medical College and Hospital, Sangli 416416.
Journal of the Indian Medical Association
|January 31, 2013
Summary
Gastro-intestinal stromal tumours (GISTs) are rare but common non-epithelial G.I. tumours, often poorly understood and treated, especially in India. This case highlights diagnostic and management challenges.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Gastro-intestinal stromal tumours (GISTs) are rare non-epithelial neoplasms of the digestive tract.
- GISTs are the most common mesenchymal tumours of the G.I. tract but are often underestimated and inadequately treated, particularly in peripheral centers in India.
- These tumours exhibit poor response to conventional chemotherapy and radiotherapy, necessitating accurate diagnosis and tailored management strategies.
Observation:
- A 35-year-old male presented with symptoms of subacute intestinal obstruction.
- Investigations revealed moderate anemia, elevated serum AST (SGOT), and mild hypoproteinaemia.
- Surgical exploration identified a jejunal tumour, which was subsequently resected.
Findings:
- Histopathological examination indicated a spindle cell tumour, consistent with a GIST of intermediate risk.
- Immunohistochemical analysis confirmed the diagnosis with strong c-kit (CD117) positivity.
Implications:
- Accurate diagnosis of GISTs is crucial for appropriate patient management.
- This case underscores the importance of immunohistochemistry in confirming GIST diagnoses.
- Timely referral to specialized oncology centers is vital for optimal GIST treatment and patient outcomes.