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Related Concept Videos

Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Types of Selection01:46

Types of Selection

Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Dose-Response Relationship: Selectivity and Specificity01:25

Dose-Response Relationship: Selectivity and Specificity

Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and β2-adrenergic receptors...
Woodward–Hoffmann Selection Rules and Microscopic Reversibility01:34

Woodward–Hoffmann Selection Rules and Microscopic Reversibility

Electrocyclic reactions, cycloadditions, and sigmatropic rearrangements are concerted pericyclic reactions that proceed via a cyclic transition state. These reactions are stereospecific and regioselective. The stereochemistry of the products depends on the symmetry characteristics of the interacting orbitals and the reaction conditions. Accordingly, pericyclic reactions are classified as either symmetry-allowed or symmetry-forbidden. Woodward and Hoffmann presented the selection criteria for...
Controls in Experiments01:13

Controls in Experiments

When conducting an experiment, it is crucial to have control to reduce bias and accurately measure the dependent variables. It also marks the results more reliable. Controls are elements in an experiment that have the same characteristics as the treatment groups but are not affected by the independent variable. By sorting these data into control and experimental conditions, the relationship between the dependent and independent variables can be drawn. A randomized experiment always includes a...

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Related Experiment Video

Updated: May 14, 2026

Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction
16:23

Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction

Published on: February 26, 2014

Post SELECT: selenium on trial.

Arun K Sharma1, Shantu Amin

  • 1Department of Pharmacology, Penn State College of Medicine, Penn State Hershey Cancer Institute, CH72, 500 University Drive, Hershey, PA 17033, USA. aks14@psu.edu

Future Medicinal Chemistry
|January 31, 2013
PubMed
Summary
This summary is machine-generated.

Selenium compounds show promise for cancer prevention and treatment. Despite the SELECT trial

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Simulation of a Scaled Assembly Process with Collaboration of a Robotic Arm and Monitoring through a Vision System for Quality Control
05:47

Simulation of a Scaled Assembly Process with Collaboration of a Robotic Arm and Monitoring through a Vision System for Quality Control

Published on: August 29, 2025

Related Experiment Videos

Last Updated: May 14, 2026

Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction
16:23

Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction

Published on: February 26, 2014

Simulation of a Scaled Assembly Process with Collaboration of a Robotic Arm and Monitoring through a Vision System for Quality Control
05:47

Simulation of a Scaled Assembly Process with Collaboration of a Robotic Arm and Monitoring through a Vision System for Quality Control

Published on: August 29, 2025

Area of Science:

  • Biochemistry
  • Oncology
  • Pharmacology

Background:

  • Selenium is an essential trace element vital for human and animal health.
  • Selenium compounds have demonstrated potential as cancer chemopreventive and chemotherapeutic agents.
  • The SELECT trial's outcome negatively impacted enthusiasm for selenium-based drug development.

Purpose of the Study:

  • To re-evaluate the potential of selenium compounds in cancer therapy.
  • To analyze the diverse mechanisms, bioavailability, and efficacy of selenium compounds based on chemical structure.
  • To highlight the importance of selenium in developing future cancer chemopreventive and chemotherapeutic drugs.

Main Methods:

  • Literature review of selenium compounds, their mechanisms, bioavailability, and efficacy.
  • Analysis of chemical structures to understand structure-activity relationships.
  • Examination of newly developed selenium compounds and their therapeutic potential.

Main Results:

  • The SELECT trial's failure with selenomethionine does not negate the potential of all selenium compounds.
  • Diverse selenium compounds exhibit varied mechanisms of action and efficacy.
  • Newly developed selenium compounds show significant promise for therapeutic applications.

Conclusions:

  • Selenium compounds remain highly important for future cancer chemoprevention and chemotherapy.
  • Further research into novel selenium compounds is warranted for effective cancer treatment strategies.
  • The therapeutic potential of selenium compounds is significant and should be further explored.