Related Experiment Video
Updated: May 14, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Innate immune signals in autoimmune and autoinflammatory uveitis
James T Rosenbaum1, Hyun Woong Kim
1Oregon Health & Science University, Casey Eye Institute, Portland, OR, USA. rosenbaj@ohsu.edu
Abstract:
Although traditionally the adaptive immune system has been viewed as the essential contributor to autoimmune diseases, the evidence implicating the innate immune system has grown considerably in recent years. Several multisystem inflammatory diseases affect the uvea and occur as a result of a mutation in a gene coding for a component of the innate immune system. Diseases associated with uveitis such as ankylosing spondylitis, sarcoidosis, Behcet's disease and inflammatory bowel disease can best be conceptually understood by hypotheses that consider microbial infection and innate immunity as contributing factors.
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