Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 14, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

Uveitis in mouse and man.

John V Forrester1, Izabela P Klaska, Tian Yu

  • 1Ocular Immunology Laboratory, Section of Immunology and Infection, Division of Applied Medicine, Institute of Medical Sciences, University of Aberdeen, Scotland. j.forrester@abdn.ac.uk

International Reviews of Immunology
|January 31, 2013
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Myeloid Cell Protein Tyrosine Phosphatase 1B Drives Retinal Neurodegeneration in Diabetic Mice.

Diabetes·2026
Same author

Infection control in the brain and the eye.

Acta ophthalmologica·2026
Same author

Antigen-specific polyfunctional cytotoxic T cells differentiate intraocular from peripheral blood immune responses in posterior uveitis.

Clinical & translational immunology·2025
Same author

Protocol for isolating and characterizing human vitreous immune cell infiltrates by flow cytometry and single-cell transcriptomic studies.

STAR protocols·2025
Same author

Evolution of the ocular immune system.

Eye (London, England)·2024
Same author

Immune Privilege Furnishes a Niche for Latent Infection.

Frontiers in ophthalmology·2024
Same journal

Leptin in metabolic-immune crosstalk: Mechanisms of T cell regulation and implications for autoimmune disease therapy.

International reviews of immunology·2026
Same journal

Metabolic alterations in the tumor microenvironment influence the anti-tumor immune function of CD8<sup>+</sup> T cells via epigenetic modifications.

International reviews of immunology·2026
Same journal

Macrophage markers and gene signature profiling reveals mesenchymal stem cells mediated immune modulation in Plasmodium berghei ANKA infection.

International reviews of immunology·2026
Same journal

Natural antigen landscape shaping intestinal Treg cells: Self, diet, and microbiota.

International reviews of immunology·2026
Same journal

Upregulation of ADAM10 reinforces CD8<sup>+</sup> T cells toward exhaustion in the TME.

International reviews of immunology·2026
Same journal

PTX3 promotes macrophage efferocytosis and inflammation resolution in granulomatous mastitis.

International reviews of immunology·2026
See all related articles

Uveitis, a major cause of blindness, may share common origins between infectious and non-infectious forms. Research suggests latent infections could trigger autoimmune responses, blurring the lines between these uveitis classifications.

Area of Science:

  • Ophthalmology
  • Immunology
  • Autoimmune Diseases

Background:

  • Uveitis is a significant cause of vision loss, often categorized as infectious or non-infectious.
  • Non-infectious uveitis is widely regarded as an autoimmune condition, primarily based on mouse models.
  • Existing experimental models mimic anterior, intermediate, and posterior uveitis.

Purpose of the Study:

  • To investigate the potential role of latent infections in immune-mediated uveitis.
  • To explore shared pathogenic mechanisms between infectious and non-infectious uveitis.
  • To question the exclusive autoimmune basis of non-infectious uveitis.

Main Methods:

  • Utilizing experimental mouse models of uveitis.
  • Analyzing the role of innate immune cells and pathogen recognition receptors (PRRs).

More Related Videos

Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis
06:57

Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis

Published on: March 8, 2018

Evisceration of Mouse Vitreous and Retina for Proteomic Analyses
02:39

Evisceration of Mouse Vitreous and Retina for Proteomic Analyses

Published on: April 3, 2011

Related Experiment Videos

Last Updated: May 14, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis
06:57

Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis

Published on: March 8, 2018

Evisceration of Mouse Vitreous and Retina for Proteomic Analyses
02:39

Evisceration of Mouse Vitreous and Retina for Proteomic Analyses

Published on: April 3, 2011

  • Considering mechanisms like antigenic cross-reactivity and molecular mimicry.

    • Main Results:

    • Uveitis models show a predominant Th1/Th17 immune response.
    • Innate immunity is crucial for disease induction and tissue damage.
    • Experimental models often use adjuvants to activate the innate immune system.

    Conclusions:

    • Latent or residual infections may drive immune-mediated uveitis, even without active infection.
    • Antigenic cross-reactivity and molecular mimicry are potential pathogenic pathways.
    • Infectious and non-infectious uveitis might share common underlying mechanisms involving residual antigens acting as adjuvants.