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Updated: May 14, 2026

A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue
Published on: June 7, 2017
The immunological basis of degenerative diseases of the eye
Robert B Nussenblatt1, Baoying Liu, Lai Wei
1Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20814, USA. DrBob@nei.nih.gov
Abstract:
It has become clear that disorders that were once considered "degenerative" have complex mechanisms, with many having been shown to have immune mediation as part of the disease process. These include arteriosclerotic heart disease and Alzheimer's disease. Indeed, several ocular disorders that once fell into the "degenerative" category meet this criterion as well. Immune mediation has been shown to be a part of many of the most common ocular disorders, and not just that of uveitis, or ocular inflammatory disease.
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