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Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time
06:01

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time

Published on: July 26, 2024

Associations between medication use and functional gastrointestinal disorders: a population-based study.

R S Choung1, G R Locke, C D Schleck

  • 1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

Neurogastroenterology and Motility
|January 31, 2013
PubMed
Summary
This summary is machine-generated.

Proton pump inhibitor (PPI) use is common and linked to irritable bowel syndrome (IBS) and other functional gastrointestinal syndromes. This study investigated medication use and its association with GI symptoms in a community-based cohort.

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Area of Science:

  • Gastroenterology
  • Epidemiology
  • Pharmacology

Background:

  • Functional gastrointestinal (GI) syndromes are highly prevalent.
  • Unrecognized medication use may contribute to the prevalence of these syndromes.
  • Proton pump inhibitors (PPIs), antidepressants, and narcotics are commonly used medications.

Purpose of the Study:

  • To estimate the prevalence of PPI, antidepressant, and narcotic use in the general population.
  • To evaluate the association between these medications and functional GI syndromes.
  • To adjust for potential confounders in the analysis.

Main Methods:

  • A community-based cohort of Olmsted County, MN residents was surveyed in 2008-2009.
  • A validated bowel disease questionnaire was used to collect data on medication usage and GI symptoms.
  • Multiple variable logistic regression models assessed the association between medication use and GI symptom complexes.

Main Results:

  • Proton pump inhibitor (PPI) use was reported by 20% of respondents.
  • PPI use was significantly associated with irritable bowel syndrome (IBS) (OR=1.4), GERD (OR=3.5), and dyspepsia (OR=2.0).
  • Antidepressant use was associated with bloating (OR=1.6).

Conclusions:

  • Proton pump inhibitor (PPI) use is common in the general population.
  • PPI use is associated with irritable bowel syndrome (IBS), GERD, and dyspepsia.
  • Medications like PPIs may influence intestinal transit or gut microbiota, contributing to functional GI syndromes.