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Activity-dependent synaptic plasticity and metaplasticity in spinal motor networks
Sandrine S Bertrand1, Jean-René Cazalets
1Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, CNRS UMR5287, Université de Bordeaux, Bordeaux, France. sandrine.bertrand@u-bordeaux2.fr
Current Pharmaceutical Design
|January 31, 2013
Summary
Activity-dependent synaptic plasticity (ADSP) and metaplasticity are crucial for neuronal network function. These mechanisms, including neuromodulation, are vital for sensorimotor networks and motor circuit assembly in the spinal cord.
Area of Science:
- Neuroscience
- Neurophysiology
- Motor Control
Background:
- Neuronal network properties adapt to stimuli via plasticity.
- Synaptic strength changes dynamically, a process known as activity-dependent synaptic plasticity (ADSP).
- Metaplasticity refers to the modulation of ADSP by prior activity.
Purpose of the Study:
- To review findings on ADSP and its neuromodulation in vertebrate sensorimotor networks.
- To discuss the role of ADSP and neuromodulation in motor circuit assembly.
- To explore ADSP and metaplasticity in the context of spinal cord function and injury.
Main Methods:
- Review of existing literature on ADSP and neuromodulation.
- Analysis of findings in vertebrate sensorimotor networks.
- Discussion of physiological and pathophysiological roles in motor circuits.
Main Results:
- ADSP and metaplasticity are essential for information processing in neuronal networks.
- Central pattern generators (CPGs) rely on synaptic transmission, membrane properties, and neuromodulation.
- The spinal cord exhibits plastic and metaplastic properties relevant to normal function and injury.
Conclusions:
- ADSP and metaplasticity are fundamental to neuronal function and motor control.
- Neuromodulation significantly influences ADSP in sensorimotor networks.
- Understanding these mechanisms is critical for spinal cord physiology and recovery after injury.
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