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Published on: February 14, 2011

Safety of posaconazole

Pauline L Jacinto1, Pranatharthi Chandrasekar

  • 1Wayne State University School of Medicine, Detroit Medical Center, Division of Infectious Diseases, Department of Internal Medicine, Detroit, USA. pjacinto@med.wayne.edu

Expert Opinion on Drug Safety
|January 31, 2013
PubMed
Abstract

Insights

Posaconazole is generally safe for treating invasive fungal infections. However, its limited intravenous formulation and variable oral absorption hinder widespread clinical use.

Area of Science:

  • Pharmacology
  • Infectious Diseases

Background:

  • Invasive fungal infections (IFI) pose significant challenges in immunocompromised patients.
  • Appropriate antifungal drug selection requires knowledge of pharmacokinetics, drug interactions, and safety profiles.

Purpose of the Study:

  • To review the safety profile of posaconazole.
  • To examine posaconazole's potential for drug-drug interactions.

Main Methods:

  • Literature review focusing on posaconazole's safety and drug interactions.
  • Analysis of adverse effects and pharmacokinetic data.

Main Results:

  • Posaconazole demonstrates a generally favorable safety profile and is well-tolerated.
  • Drug-drug interactions associated with posaconazole require careful consideration.

Conclusions:

  • Posaconazole is considered safe and well-tolerated for managing IFIs.
  • The lack of an intravenous formulation and variable oral bioavailability of the suspension limit its broader clinical application.

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