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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

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Updated: May 14, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

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MicroRNAs in malignant melanoma.

Daniel Völler1, Corinna Ott, Anja Bosserhoff

  • 1Institute of Pathology, Molecular Pathology, University of Regensburg, Regensburg, Germany.

Clinical Biochemistry
|January 31, 2013
PubMed
Summary

MicroRNAs (miRNAs) are key regulators in melanoma development. This review explores their role in skin cancer and potential as diagnostic biomarkers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Melanoma is an aggressive skin cancer with rising incidence.
  • Metastatic melanoma shows resistance to conventional therapies, reducing survival rates.
  • Novel biomarkers are crucial for early detection and improved prevention strategies.

Purpose of the Study:

  • To review the current understanding of microRNA (miRNA) involvement in melanoma.
  • To explore the role of specific miRNAs and their targets in melanomagenesis.
  • To assess the potential of miRNAs as diagnostic biomarkers for melanoma.

Main Methods:

  • Literature review of studies on microRNAs and melanoma.
  • Analysis of miRNA post-transcriptional gene regulation mechanisms.

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  • Synthesis of data on miRNA expression patterns in melanoma.

    • Main Results:

    • MicroRNAs play a significant role in the molecular pathways of melanoma.
    • Specific miRNAs and their mRNA targets are implicated in melanoma progression.
    • Dysregulated miRNA expression is a hallmark of melanoma.

    Conclusions:

    • MicroRNAs are critical regulators in melanoma development.
    • miRNAs hold promise as sensitive and specific biomarkers for melanoma diagnosis and prognosis.
    • Targeting miRNAs may offer new therapeutic strategies for melanoma.