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An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
Gut microbiota and metabolic disorders: How prebiotic can work?
Nathalie M Delzenne1, Audrey M Neyrinck, Patrice D Cani
1Université catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Avenue Mounier 73, Box B1.73.11, B-1200 Brussels, Belgium. nathalie.delzenne@uclouvain.be
The British Journal of Nutrition
|January 31, 2013
Summary
Dietary fibers with prebiotic properties can alter gut microbiota composition, influencing host metabolism. This review explores their potential for managing obesity and related metabolic issues.
Area of Science:
- Microbiology
- Metabolism
- Nutrition Science
Background:
- Gut microbiota composition varies between obese and lean individuals, and in patients with metabolic diseases like non-alcoholic steatohepatitis.
- Obesity and associated conditions are linked to dysbiosis, an imbalance in gut microbial communities.
- Understanding these differences is crucial for developing targeted interventions.
Purpose of the Study:
- To review how prebiotic dietary fibers modify gut microbiota and impact host gene expression and metabolism.
- To evaluate the therapeutic potential of prebiotic fibers in managing obesity and metabolic disturbances.
- To synthesize current evidence from animal and human studies.
Main Methods:
- Literature review of experimental data in animals and observational/intervention studies in humans.
- Analysis of studies investigating the effects of prebiotic fibers on gut microbiota.
- Examination of research on host gene expression and metabolic changes.
Main Results:
- Prebiotic fibers can beneficially alter gut microbiota composition and activity.
- These alterations can lead to modulation of host gene expression and improved metabolic parameters.
- Evidence suggests a role for prebiotics in managing obesity and related metabolic disorders.
Conclusions:
- Modulating the gut microbiota with prebiotic dietary fibers offers a promising strategy for obesity and metabolic disease management.
- Further research and clinical trials are warranted to fully establish efficacy.
- Dietary interventions targeting the gut microbiome hold significant therapeutic potential.
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