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Updated: Aug 14, 2026

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
[A child with pneumonia caused by a multiresistant pneumococcus]
1Wilhelmina Kinderziekenhuis, Laboratorium voor Microbiologie, Utrecht.
Abstract:
Strains of Streptococcus pneumoniae resistant to penicillin have not previously been reported in The Netherlands. Now we have to report the isolation in November 1988 of a multiresistant pneumococcus (minimal inhibitory concentration 2 mg/l) from sputum of a three-year-old child from Poland. We advise isolating patients from abroad (Spain, Poland) in hospital and checking their bacteriological status to prevent introduction of penicillin resistant pneumococci into the Dutch population.
Insights
Penicillin-resistant Streptococcus pneumoniae, previously unrecorded in the Netherlands, was identified in a child from Poland. This highlights the need for isolating foreign patients to prevent the spread of resistant bacteria.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Penicillin resistance in Streptococcus pneumoniae was previously unreported in The Netherlands.
- Streptococcus pneumoniae is a common cause of bacterial infections, including pneumonia and meningitis.
Observation:
- In November 1988, a multiresistant strain of Streptococcus pneumoniae was isolated from a three-year-old child.
- The child, originating from Poland, presented with sputum containing the resistant pneumococcus.
Findings:
- The isolated pneumococcus exhibited high-level resistance to penicillin, with a minimal inhibitory concentration of 2 mg/l.
- This marked the first documented instance of penicillin-resistant Streptococcus pneumoniae in The Netherlands.
Implications:
- The findings underscore the potential for introducing antibiotic-resistant bacteria through international travel and migration.
- Implementing isolation protocols for patients arriving from high-risk regions (e.g., Spain, Poland) is crucial.
- Routine bacteriological surveillance of foreign patients is recommended to prevent the establishment of resistant pneumococcal strains in the Dutch population.
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