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Published on: May 2, 2017
Fluid management in the critically ill child
1Great Ormond Street Hospital NHS Foundation Trust, London, WC1N 3JH, UK, sainath.raman@ucl.ac.uk.
Insights
Fluid management in critically ill children requires a biphasic approach. Early aggressive resuscitation improves shock outcomes, while later fluid restriction reduces hospital stay and complications.
Area of Science:
- Pediatric critical care medicine
- Fluid resuscitation and management
- Shock and sepsis in children
Background:
- Fluid management significantly influences the course and outcomes of critical illness in children.
- Current strategies often involve aggressive fluid resuscitation for shock, particularly septic shock.
- However, the benefits and risks of aggressive fluid administration require nuanced consideration based on patient factors and care setting.
Purpose of the Study:
- To review the biphasic fluid management strategy in critically ill children.
- To highlight the shift in fluid balance needs from resuscitation to maintenance phases.
- To identify knowledge gaps and the need for pediatric-specific fluid management trials.
Main Methods:
- Review of existing literature on fluid management in critically ill children and adults.
- Analysis of fluid balance patterns in early shock versus chronic critical illness phases.
- Synthesis of data regarding fluid resuscitation and maintenance regimens.
Main Results:
- Aggressive fluid resuscitation in early shock, especially septic shock, improves outcomes.
- Critically ill children often retain free water and have reduced insensible losses post-resuscitation.
- Limiting positive fluid balance in later stages correlates with shorter hospital stays and fewer complications.
Conclusions:
- A biphasic fluid management strategy is recommended for critically ill children.
- Distinguishing between early shock and chronic critical illness phases is crucial for appropriate fluid management.
- High-quality trials are urgently needed to guide resuscitation and maintenance fluid regimens specifically for pediatric critical care.
Abstract:
Fluid management has a major impact on the duration, severity and outcome of critical illness. The overall strategy for the acutely ill child should be biphasic. Aggressive volume expansion to support tissue oxygen delivery as part of early goal-directed resuscitation algorithms for shock--especially septic shock--has been associated with dramatic improvements in outcome. Recent data suggest that the cost-benefit of aggressive fluid resuscitation may be more complex than previously thought, and may depend on case-mix and the availability of intensive care. After the resuscitation phase, critically ill children tend to retain free water while having reduced insensible losses. Fluid regimens that limit or avoid positive fluid balance are associated with a reduced length of hospital stay and fewer complications. Identifying the point at which patients change from the 'early shock' pattern to the later 'chronic critical illness' pattern remains a major challenge. Very little data are available on the choice of fluids, and most of the information that is available arises from studies of critically ill adults. There is therefore an urgent need for high-quality trials of both resuscitation and maintenance fluid regimens in critically ill children.
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