Maternal smoking during pregnancy and childhood overweight and fat distribution: the KOALA Birth Cohort Study
S H Timmermans1, M Mommers, J S Gubbels
1Department of Epidemiology, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre, Maastricht, The Netherlands.
Insights
Maternal smoking during pregnancy leads to lower birth weight and weight catch-up, increasing the risk of childhood overweight. This association with body mass index (BMI) and fat distribution develops with age.
Area of Science:
- Obstetrics and Gynecology
- Pediatrics
- Public Health
Background:
- Maternal smoking during pregnancy is linked to childhood overweight.
- The impact on childhood fat distribution remains unclear.
Purpose of the Study:
- To investigate the long-term effects of maternal smoking during pregnancy on childhood overweight.
- To examine the association with childhood fat distribution.
Main Methods:
- The KOALA Birth Cohort Study followed 2698 mother-child pairs.
- Data collected via questionnaires and home visits.
- Analyzed birth weight, BMI, waist circumference, and skinfold thickness using regression and GEE.
Main Results:
- Maternal smoking correlated with lower birth weight and increased weight gain in the first year.
- Children of mothers who smoked had a higher risk of exceeding the 85th percentile for BMI, waist circumference, and skinfold thickness at school age.
Conclusions:
- Maternal smoking during pregnancy is associated with lower birth weight and subsequent weight catch-up.
- This pattern contributes to the development of overweight in childhood and altered fat distribution.
Unlabelled:
What is already known about this subject There is an association between maternal smoking during pregnancy and higher body mass index (BMI) and overweight in childhood. What this study adds The association between maternal smoking during pregnancy and childhood overweight develops with age, starting with a lower birth weight, followed by weight catch-up in the first year after birth, finally leading to overweight at school age. Children of mothers who had smoked during pregnancy had a higher risk of exceeding the 85th percentile of BMI, waist circumference and total skinfold thickness at school age.
Background:
Maternal smoking during pregnancy is associated with childhood overweight, but the association with fat distribution is not clear.
Objective:
To explore the longitudinal association between smoking during pregnancy and childhood overweight and fat distribution.
Methods:
In the KOALA Birth Cohort Study, repeated questionnaires were administered to 2698 mother-child pairs, including questions on smoking at 14 and 34 weeks of pregnancy. Main outcomes were birth weight, weight gain in the first year, body mass index (BMI) z-scores and overweight (BMI ≥85th percentile) at 1, 2, 4-5 and 6-7 years (n = 1730) and waist circumference and four skinfold thicknesses measured at home visits at age 6-7 years in a subgroup (n = 418). We used multivariable linear and logistic regression, with generalized estimating equations (GEE) for repeated measurements.
Results:
Maternal smoking was associated with lower birth weight, higher weight gain in the first year and increasing overweight after infancy (change with age P = 0.02 in the GEE). Maternal smoking vs. non-smoking during pregnancy was associated with a higher risk of the child exceeding the 85th percentile of BMI (adjusted odds ratio [aOR] 3.72; 95% CI 1.33-10.4), waist circumference (aOR 2.65; 95% CI 1.06-6.59) and sum of skinfold thicknesses (aOR 4.45; 95% CI 1.63-12.2) at the age of 6-7 years.
Conclusions:
Maternal smoking during pregnancy is associated with lower birth weight, weight catch-up and development of overweight into childhood.
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