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Graphene oxide-based fluorescent biosensor for protein detection via terminal protection of small-molecule-linked DNA

Yue He1, Xiaojing Xing, Hongwu Tang

  • 1College of Chemistry and Molecular Sciences, Research Center for Nanobiology and Nanomedicine-MOE 985 Innovative Platform, Wuhan Institute of Biotechnology, and State Key Laboratory of Virology, Wuhan University, Wuhan 430072, PR China.

Small (Weinheim an Der Bergstrasse, Germany)
|January 31, 2013
PubMed

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...