Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches.

Immunity·2026
Same author

Proteoglycofili are glycosaminoglycan-containing fibrillar components released by neutrophils to neutralize bacteria.

Cell reports·2025
Same author

Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation.

The Journal of experimental medicine·2025
Same author

Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs.

Immunity·2024
Same author

Reciprocal inhibition of NOTCH and SOX2 shapes tumor cell plasticity and therapeutic escape in triple-negative breast cancer.

EMBO molecular medicine·2024
Same author

Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo.

Nature·2024

Related Experiment Video

Updated: May 14, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Stem cells living with a Notch.

Ute Koch1, Rajwinder Lehal, Freddy Radtke

  • 1Ecole Polytechnique Fédérale de Lausanne (EPFL), School of Life Science, SwissInstitute for Experimental Cancer Research (ISREC), Station 19, 1015 Lausanne, Switzerland. freddy.radtke@epfl.ch

Development (Cambridge, England)
|January 31, 2013
PubMed
Summary
This summary is machine-generated.

Notch signaling is crucial for development and tissue maintenance across species. This review compares its roles in stem cells from flies, fish, and mice, revealing conserved and divergent functions.

More Related Videos

Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo
09:19

Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo

Published on: February 15, 2021

Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles
11:35

Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles

Published on: December 9, 2022

Related Experiment Videos

Last Updated: May 14, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo
09:19

Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo

Published on: February 15, 2021

Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles
11:35

Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles

Published on: December 9, 2022

Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Cell Signaling

Background:

  • Notch signaling is an evolutionarily conserved cell-to-cell communication pathway.
  • It plays fundamental roles in embryonic development and adult tissue homeostasis.
  • Key functions include regulating stem cell maintenance, differentiation, and cellular balance.

Purpose of the Study:

  • To review the multifaceted roles of Notch signaling specifically in stem cells.
  • To compare and contrast Notch pathway functions across different species (flies, fish, mice).
  • To identify conserved and divergent mechanisms of Notch signaling in various stem cell types.

Main Methods:

  • Comparative analysis of existing research on Notch signaling in stem cells.
  • Literature review focusing on studies in Drosophila, zebrafish, and Mus musculus.
  • Synthesis of data to highlight interspecies and inter-tissue similarities and differences.

Main Results:

  • Notch signaling is essential for stem cell self-renewal and differentiation across diverse organisms.
  • Species-specific variations in Notch pathway components and downstream effects exist.
  • Tissue context significantly influences Notch-mediated stem cell regulation.

Conclusions:

  • Notch signaling is a critical regulator of stem cell behavior with both conserved and unique roles.
  • Understanding these conserved and divergent roles is key to harnessing stem cells therapeutically.
  • Further research is needed to fully elucidate the complex interplay of Notch signaling in different stem cell niches.