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Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition
Published on: June 16, 2019
Human pluripotent stem cells: an emerging model in developmental biology
1Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10065, USA. zhuz@mskcc.org
Development (Cambridge, England)
|January 31, 2013
Summary
Human pluripotent stem cells (hPSCs) offer a novel model for studying human embryonic development. These cells complement traditional model organisms and enable gene discovery through advanced screening technologies.
Area of Science:
- Developmental biology
- Stem cell research
- Human embryonic development
Background:
- Classic model organisms have historically advanced developmental biology.
- Human pluripotent stem cells (hPSCs), encompassing embryonic and induced pluripotent stem cells, represent a significant new model system.
- hPSCs provide unique advantages for studying human development.
Purpose of the Study:
- To discuss how hPSC studies complement traditional model organism research.
- To explain the recapitulation of human embryonic development using hPSCs in vitro.
- To summarize genetic tools for studying gene function during hPSC differentiation.
Main Methods:
- Utilizing hPSCs (human embryonic stem cells and human induced pluripotent stem cells) as a model system.
- Employing recently developed genetic tools for gene function analysis.
- Leveraging high-throughput screening technologies.
Main Results:
- hPSCs effectively model key aspects of human embryonic development in vitro.
- New genetic tools facilitate the investigation of gene function during hPSC differentiation.
- hPSCs, combined with screening technologies, show potential for revolutionizing gene discovery.
Conclusions:
- hPSCs are a valuable addition to developmental biology, complementing classic models.
- In vitro recapitulation of human development using hPSCs is feasible.
- Advancements in genetic tools and screening technologies enhance the utility of hPSCs for gene discovery in mammalian development.
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