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Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

In vitro radiosensitization by pentoxifylline does not depend on p53 status

John M Akudugu1, Antonio M Serafin, Lothar J F Böhm

  • 1Radiobiology Unit, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa. jakudugu@sun.ac.za

International Journal of Radiation Biology
|February 1, 2013
PubMed
Summary

Pentoxifylline enhances radiation therapy by increasing G2/M cell cycle arrest, independent of p53 status. Its effectiveness relies on the extent of this radiation-induced block, offering potential for targeted cancer treatments.

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