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Updated: May 14, 2026
08:57
Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
Plexiform schwannoma of the rectum
Shinya Kawaguchi1, Rei Yamamoto, Mitsuhiro Yamamura
1Department of Gastroenterology, Ise Red Cross Hospital, Ise, Japan.
Summary
This study reports the first case of a rectal plexiform schwannoma, a rare benign nerve tumor, successfully treated with endoscopic submucosal dissection (ESD). This minimally invasive technique offers a new option for managing this rare visceral tumor.
Area of Science:
- Gastroenterology and Surgical Oncology
- Pathology and Molecular Diagnostics
Background:
- Plexiform schwannomas are rare, benign peripheral nerve sheath tumors.
- Visceral localization of plexiform schwannomas is exceptionally uncommon, with only six prior cases reported.
- Rectal schwannomas are exceedingly rare, making this case unique.
Observation:
- A 77-year-old woman presented with anal pain due to a 20mm rectal submucosal tumor.
- Endoscopic submucosal dissection (ESD) was utilized for tumor resection.
- Histopathological analysis confirmed a plexiform schwannoma composed of Antoni A tissue, positive for S-100.
Findings:
- The rectal tumor was successfully resected using ESD, a minimally invasive endoscopic approach.
- Immunohistochemical analysis confirmed the diagnosis, showing positivity for S-100 and negativity for α-smooth muscle actin, c-kit, and CD-34.
- No recurrence was observed during a 2-year follow-up period.
Implications:
- This case establishes ESD as a viable and effective treatment modality for rectal plexiform schwannoma.
- Highlights the importance of considering rare diagnoses in visceral submucosal tumors.
- Contributes to the limited literature on visceral plexiform schwannomas and their management.
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