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Related Experiment Video

Updated: May 14, 2026

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

Controlled drug-release system based on pH-sensitive chloride-triggerable liposomes.

Mark P Wehunt¹, Christine A Winschel, Ali K Khan

¹Department of Chemistry, Virginia Commonwealth University, 1001 West Main Street, Richmond, Virginia 23284, USA.

Journal of Liposome Research

|February 1, 2013

Summary

Researchers developed novel pH-sensitive liposomes for controlled drug delivery. These liposomes release drugs in a stepwise manner, triggered by pH changes, showing promise for in vivo applications.

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A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters

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Published on: April 20, 2015

Area of Science:

Biomaterials Science
Drug Delivery Systems
Nanotechnology

Background:

Controlled drug release is crucial for therapeutic efficacy and minimizing side effects.
Liposomes are versatile nanocarriers, but precise control over drug release remains a challenge.
pH-responsive systems offer potential for targeted and triggered drug delivery.

Purpose of the Study:

To synthesize novel pH-sensitive lipids for liposome formulation.
To develop a liposomal drug delivery system with triggered, stepwise release.
To evaluate the in vivo potential of these pH-sensitive liposomes.

Main Methods:

Synthesis of novel pH-sensitive lipids.
Formulation of liposomes with varying internal NaCl concentrations.
Triggering drug release using an HCl cotransporter and NaCl solution.
Assessing liposome stability in the presence of human serum albumin.
Evaluating cytotoxicity of liposomes on cells.

Main Results:

Successfully synthesized pH-sensitive lipids for liposome formulation.
Demonstrated triggered, stepwise drug release from liposomes in response to pH changes.
Liposomes exhibited stability against human serum albumin.
Liposomes showed no significant cytotoxicity at pharmacologically relevant concentrations.

Conclusions:

The developed pH-sensitive liposomes offer a novel platform for controlled drug release.
The stepwise release mechanism provides temporal control over drug delivery.
The system's biocompatibility and stability suggest potential for in vivo applications.