The ERdj5-Sel1L complex facilitates cholera toxin retrotranslocation

Jeffrey M Williams1, Takamasa Inoue, Lindsey Banks

  • 1Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48103, USA.

Summary

The ER-resident factor ERdj5 and Sel1L facilitate cholera toxin (CT) retrotranslocation to the cytosol. ERdj5 links to the Hrd1 complex via Sel1L, promoting toxin release for degradation.

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