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Factors affecting left ventricular synchronicity in hypertensive patients: are arterial stiffness and central blood

Abdulkadir Kırış1, Gülhanım Kırış, Kayıhan Karaman

  • 1Department of Cardiology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey. akiris79@yahoo.com

Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir
|February 1, 2013
PubMed

Insights

Hypertension significantly increases left ventricular (LV) dyssynchrony, linked to higher central systolic blood pressure. Arterial stiffness and central blood pressure are key factors in this condition.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Vascular Physiology

Background:

  • Left ventricular (LV) dyssynchrony is prevalent in hypertension and linked to LV hypertrophy.
  • Arterial stiffness (AS) and central blood pressures contribute to hypertension-related end-organ damage.

Purpose of the Study:

  • To investigate the relationship between arterial stiffness, central blood pressures, and LV dyssynchrony in newly diagnosed hypertensive patients.

Main Methods:

  • Echocardiographic tissue synchrony imaging was used to assess LV dyssynchrony in 35 hypertensive patients and 40 controls.
  • Arterial stiffness parameters (PWV, AIx@75) and central blood pressures were measured using applanation tonometry.

Main Results:

  • Hypertensive patients exhibited significantly prolonged LV dyssynchrony indices compared to controls (p<0.001).
  • Higher PWV, AIx@75, and central systolic/diastolic pressures were observed in hypertensive patients.
  • Multivariable analysis identified central systolic BP, LV mass index, and BMI as independent predictors of LV dyssynchrony.

Conclusions:

  • Central systolic blood pressure independently predicts LV dyssynchrony in newly diagnosed hypertension.
  • Augmentation index (AIx@75) did not show an independent effect on LV synchronicity in this cohort.
Abstract

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